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Pallidal Stimulation for Parkinson's Disease, Two Targets Neurol 49:1564-1569, Bejjani,B.,et al, 1997 See this aricle in Pubmed Article Abstract Our results indicate that stimulation had a striking different effect on parkinsonism and dyskinesia when applied at two different loci of the GP and that stimulation applied in the posteroventral GP produced opposite effects on rigidity and on akinesia.We conclude that parkinsonian signs and LID are a reflection of at least two different anatomofunctional systems within the GP and that this functional organization of the GP needs to be considered when determining the optimal target for surgical treatment of PD.

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